> The Holiday Inn Express Hotel & Suites in O’Fallon, MO is located just west of St. Louis. Our hotel is convenient to Interstate 64 and is near several local attractions and businesses making it the perfect hotel for travelers looking for lodging in O’Fallon. Conveniently located near major companies such as Citi Corporation, General Motors, Mastercard, APC, Nortek, the Missouri Research Park and Progress West Hospital, our O’Fallon, MO hotel is ideal for both business and Leisure travelers. We are just minutes from historic St. Charles, Six Flags Over Mid-America and the Augusta vineyards. The St. Louis Arch, Anheuser-Busch,...