Few Hotels in Gananoque Can Match Our Features The Holiday Inn Express Hotel & Suites 1000 Islands – Gananoque, one of the newest Gananoque, Ontario hotels, is situated in the heart of the Thousand Islands. Our hotel’s location is just off Hwy 2 and close to Hwy 401. Leisure guests enjoy the convenience of our St. Lawrence River hotel’s location, which is close to historic Gananoque and the Gananoque Boat Line. Day trips to Boldt Castle, scenic cruises, sport fishing and Fort Henry are easily accessible from here. You can test your luck at the Shorelines Casino 1000 Islands, just...