Stay at the Best of Easton, PA HotelsThe Holiday Inn Express Easton is nestled in the heart of the beautiful Lehigh Valley. Our hotel’s location is just off Routes 22 and 33 and I-78, 1 mile from Easton Hospital.Business travelers to the area are pleased by our hotel’s location in Easton, PA, our friendly staff, great services, and clean and safe setting. They appreciate being 4.5 miles from St. Lukes Hospital Anderson Campus or a quick trip down Route 22 to Lehigh Valley Health Network Muhlenberg. A future trip may bring you to other popular destinations, Lafayette College, Crayola LLC,...